Le parcours de Maurice Merleau-Ponty ne peut se comprendre sans le fil rouge de la Psychanalyse : dès sa thèse, il restaure le primat de la perception et du corps sexué à la lumière de Freud et de Binswanger. A la Sorbonne, il renouvelle la Psychologie de l'enfant en y intégrant M. Klein, J. Lacan et F. Dolto. Au Collège de France plusieurs cours font des rêves et de la libido une dimension inéluctable de l'humain. De nombreux psychanalystes et psychiatres (...) se sont " laissés interroger par lui " : citons : H. Ey, A. Hesnard, P. Fédida, A. Green, J. Laplanche, J.-B. Pontalis, Luce Irigaray...Š. (shrink)

Little is in print on the development in Britain of university disciplines including the academic study of education. This paper provides a historical narrative of the study of adolescence from the 1870 Education Act to the contemporary day. Adolescence textbooks are examined in the context of changes in the education system, such as the demand for secondary education and the expansion of teacher education. Changing emphases in adolescence research are traced through various publications to illustrate curriculum developments. The important contributions (...) of Dame Olive Wheeler, Professor W. D. Wall and other leading writers on adolescence are evaluated. It is clear that in over a century of national educational provision British teachers have never faced a great choice of adolescence texts and the paper concludes with some reflections on this observation. (shrink)

Introduction.--Dualism and the new problem.--Truth and experience.--Plan and stages of the argument.--The interpretation of sense-experience: and of perceptual experience.--Understanding and the world of noumena and phenomena.--Self-conscious experience.--The sphere of reason, scientific experience.--The sphere of finite spirit, moral experience.--The sphere of absolute spirit, religious experience, contemplation.

Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...) localized Abeta to the nucleus in the presence of H2O2-mediated oxidative stress. Furthermore, primary rat fetal cerebrocortical cultures were transfected with APP and BACE1 promoter-luciferase fusions, and rat PC12 cultures were transfected with polymorphic APP promoter-CAT fusion clones. Transfected cells were treated with different Abeta peptides and/or H2O2. Abeta treatment of cell cultures produced a DNA sequence-specific response in cells transfected with polymorphic APP clones. Our results suggest the Abeta peptide may regulate its own production through feedback on its precursor protein and BACE1, leading to amyloidogenesis in AD. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Three experiments investigated the relationship between subjective experience and attentional lapses during sustained attention. These experiments employed two measures of subjective experience to examine how differences in awareness correspond to variations in both task performance and psycho-physiological measures . This series of experiments examine these phenomena during the Sustained Attention to Response Task . The results suggest we can dissociate between two components of subjective experience during sustained attention: task unrelated thought which corresponds to an absent minded disengagement from the (...) task and a pre-occupation with one's task performance that seems to be best conceptualised as a strategic attempt to deploy attentional resources in response to a perception of environmental demands which exceed ones ability to perform the task. The implications of these findings for our understanding of how awareness is maintained on task relevant material during periods of sustained attention are discussed. (shrink)

Although the title proper is certainly a misnomer, the subtitle may be adequate for a collection of fourteen fairly miscellaneous essays by a professional philosopher reaching out to a wider public. It should be said, however, that Holland believes that much of what he undertakes to "speak for can be found in Plato.".

We give a unified account of some results in the development of Polyadic Inductive Logic in the last decade with particular reference to the Principle of Spectrum Exchangeability, its consequences for Instantial Relevance, Language Invariance and Johnson's Sufficientness Principle, and the corresponding de Finetti style representation theorems.

Current thinking and research on consciousness and the brain.